Check out our free Rams vs 49ers pick and preview for NFL week 4 game in Santa Clara. See who we like to win and cover the spread in this week’s NFL matchup.

Rams vs 49ers Pick & Preview- NFL Week 4

Kickoff for this matchup between the Los Angeles Rams and San Francisco 49ers is set for 8:15 PM ET. The game will be played in Santa Clara, CA at Levi’s Stadium with ESPN carrying television coverage. The odds for this week 4 NFC West matchup have the 49ers as the -2.5 point favorite on the spread.

Rams vs 49ers Matchup at a Glance

  • Sport: NFL
  • Teams: Los Angeles Rams at San Francisco 49ers
  • Where: Santa Clara at Levi’s Stadium
  • Date: Monday, October 3rd
  • Betting Odds SF -2.5, LAR +116 | SF +-139 O/U 42.5

Will Matthew Stafford Lead The Rams To A Win In What Figures To Be A Tightly Contested Game?

The Rams head into week 4, looking for another win, as they picked up 8 point victory over the Arizona Cardinals (20-12). Not only did Los Angeles walk away with the win, but they also covered the spread as -3.5 point favorites. The two teams combined point total of 32 remained below the betting line of 48.

Compared to last year, where the Rams averaged 27.06 points per game, the team’s 20 was a disappointing performance.

Even with slightly fewer attempts than last year’s season average, Los Angeles still ran for a total of 100 yards. In addition to running for 61 yards, Cam Akers ran for 1 score.

On his way to throwing for 249 passing yards, Matthew Stafford finished with a passer rating of 103.58. Stafford walked away from last week’s game without a passing or rushing touchdown. Leading the team’s passing attack was Ben Skowronek, who finished with 66 yards, including a yards per reception figure of 16.5. Los Angeles is the ranked team in pass yards per game, averaging 234.0 overall. Currently, 76.39% of their yards come through the air, ranking them 5th in the NFL.

Heading into the game, the Rams defense has generated 7 sacks, placing them 19th in the league. However, they could be in line to see this number increase as they have accumulated hits on the quarterback at an above average rate.

Will Jimmy Garoppolo Lead The 49ers To A Win Over Los Angeles?

Heading into week 4, the 49ers will look to get back in the win column, as they are coming off a 11-10 loss to the Denver Broncos. With the loss, San Francisco failed to cover the spread, as they had a -1.5 advantage on the spread. With an over-under betting line of 45, the two teams fell below that figure as they combined for 21.

The 49ers 10 points was a below average figure compared to last year’s squad that averaged 25.12 points per game.

San Francisco struggled to run the ball last week, finishing with just 88 yards on 19 attempts. Jeff Wilson Jr. led the team with 75 rush yards and did not find the endzone.

On his way to throwing for 211 passing yards, Jimmy Garoppolo finished with a passer rating of 81.25. Garoppolo was able to find the endzone 1 time through the air. Although Deebo Samuel did not come up with a touchdown grab through the air, he was still productive with 73 yards. Averaging 27.0 attempts per game, San Francisco is ranked 30th in the league. Thus far, 53.35% of their yards through the air, which is 29 in the NFL.

While San Francisco has ranked 8th in defensive sacks, it has a QB hit percentage well below the NFL average at 23.6%.

Odds & Free Betting Analysis for this NFL Game

The 49ers will look to build off last year’s success over Los Angeles as they won both games by scores of 27-24 and 31-10.

Over the last 5 matchups between Los Angeles and San Francisco, the 49ers have won 4 of the last 5 games. The over-under record in these games sits at 1-4, with the average scoring total coming in at 42.4 points.

The San Francisco 49ers have performed well vs the spread in recent games, going 5-0-0. The Rams offense has averaged 18.0 points per game over the 5 most recent meetings with San Francisco, compared to the 49ers at 24.4.

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Rams vs 49ers Pick

  • Free Spread Prediction: 49ers -2.5