Follow along in this NFL week 18 Cardinals and 49ers pick and preview to get our insight on to who will win and cover in Santa Clara.

Cardinals vs 49ers Pick & Preview- NFL Week 18

On Sunday, January 8th at 4:25 PM ET, the San Francisco 49ers and Arizona Cardinals at Levi’s Stadium in Santa Clara, CA. FOX will carry the TV coverage for the game. The 49ers head into the game as the -14.0 point favorites over their NFC West rival.

Cardinals vs 49ers Matchup at a Glance

  • Sport: NFL
  • Teams: Arizona Cardinals at San Francisco 49ers
  • Where: Santa Clara at Levi’s Stadium
  • Date: Sunday, January 8th
  • Betting Odds SF -14.0, ARI +603 | SF -954 O/U 40.0

Will Colt McCoy And The Cardinals Keep Things Interesting vs San Francisco?

Vivid Picks Card

Want to play the odds?

Sign Up and Deposit Up to $100

Your Deposit Will be Fully Matched

New Users Only

This week, the Arizona Cardinals are hoping to get back in the win column after falling 20-19 to the Atlanta Falcons. The loss was costly, as it came against an NFC opponent. Arizona went into the game as the 6.5-point underdogs on the spread. The over-under betting total going into the game was 40, which the teams did not surpass.

On the ground, Arizona finished with a yard-per-carry figure of 4, leading to a total of 126 yards. James Conner led the team with 79 rush yards and did not find the endzone.

Last week, David Blough completed 60.0% of his passing attempts for 222 passing yards. Blough was able to find the endzone 1 time through the air. Trey McBride led the way for Arizona at receiver, finding the endzone once to go along with his 78 yards. Arizona is averaging 214.5 yards per game through the air. Going into the game, the Cardinals have thrown a total of 14.0 interceptions, coming on a passing completion percentage of 65.05% (18th).

Will The 49ers Take Care Of Business As Heavy Home Favorite?

The 49ers head into week 18 looking for another win, as they picked up 3 point victory over the Las Vegas Raiders (37-34). Leading into their last game, the team did not cover the spread as -9.5 point favorites. With their combined 41 points, the two teams exceeded the betting over-under number of 41.

Even with slightly fewer attempts than last year’s season average, San Francisco still ran for a total of 170 yards. Christian McCaffrey had a big individual game, finding the endzone in addition to his 121 rush yards.

Brock Purdy was able to rack up 284 passing yards on an overall passer rating of 95.42. Purdy found the endzone 2 times through the air. Leading the way in the passing game was Brandon Aiyuk, as he accumulated 101 yards and hauled in a touchdown. Overall, San Francisco is the 13th-ranked team in pass yards per game, with an average of 232.12. So far, 62.9% of their yards have come through the air, with a completion percentage of 65.76% (13th).

Odds & Free Betting Analysis for this NFL Game

This week, the Cardinals will be looking for some revenge, as they already have 1 loss to the 49ers this season. In the first game, Arizona fell by a score of 38-10. In addition to picking up the win, the 49ers covered the spread as -14.0 point favorites. Last year, Arizona took both of the matchups between the teams, grabbing a 31-17 win as well as a 17-10 victory.

When looking back at the recent matchups between Arizona and San Francisco, the Cardinals put together a record of 3-2. The over-under record in these games sits at 2-3, with the average scoring total coming in at 39.8 points.

The Arizona Cardinals have gone 2-2 vs the spread in these games. On average, the Cardinals have averaged 18.8 points per game in the past 5 head-to-head matchups, compared to San Francisco at 21.0.

Across the Cardinals’ last 5 road games, the team averaged 19.2 points per game while allowing 22.8. Their record vs the spread in these contests was 2-3, while going 1-4-0 straight-up.

Across their last 5 home contests, San Francisco has been good against the spread posting a mark of 4-1. Their overall mark in these games was 5-0, while averaging 28.0 points per game.

Cardinals vs 49ers Pick

  • Free Spread Prediction: 49ers -14.0