• Bills look to be one of the top teams in the NFL
  • Could end up being a defensive battle 
  • Both teams need to win

The Indianapolis Colts are traveling to Highmark Stadium to take on the Buffalo Bills in a week eleven matchup. The Colts are coming into the game with a 5-5 record. They are coming off of a 27-13 victory against the Jacksonville Jaguars.

The Bills enter the matchup with a record of 6-3. Last week, they dominated the New York Jets in a 45-17 win. Buffalo had an incredible bounce-back week after their embarrassing loss to the Jacksonville Jaguars. 

Colts vs Bills Matchup at a Glance

  • Sport: NFL
  • Teams: Indianapolis Colts at Buffalo Bills
  • Where: Orchard Park, Highmark Stadium
  • Date: November 21, 2021
  • Betting Odds: Indianapolis Colts +6.5 (-105), Buffalo Bills -6.5 (-115), Colts Moneyline (+230), Bills Moneyline (-290), Over 49 points (-110), Under 49 points (-110) (at PointsBet | at Caesars | at DraftKings | at Fanduel | at BetRivers)

Colts Preview: Would Be A Great Win to Help Their Playoff Odds

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The Colts took care of business last week against Jacksonville in a game they were heavily favored to win. This week, they have a much tougher matchup against the Buffalo Bills. The Bills have at times looked like one of the best teams in football. Their only chance at staying in this game is if their defense continues to play at an elite level.

The Bills have a very high-powered offense paired with a talented defense as well. The Colts have no hope of keeping up with the Bills if their defense cannot have their game of the year.

Bills Preview: Need This Win to Keep AFC East Off Their Backs

The Bills at times have looked like one of the best teams in football. Outside of their one collapse against Jacksonville, the Bills have looked like a team that realistically should have Super Bowl hopes. The Colts will not be an easy opponent for them. While Buffalo’s defense should not have too many struggles with Indianapolis’s offense, their defense could cause some issues.

If Buffalo’s offensive line can handle the pass rush from the Colts, they should have no problems winning this game. It is crucial for Buffalo to push the pace of the game and try to make it a shootout.

Odds & Free Betting Analysis for This NFL Game

We are picking the Bills to cover the spread and in turn their Moneyline as well. As of now, the Bills are still head and shoulders above the Colts. We are also predicting for the over to hit as Buffalo has the potential to almost cover the entire 49 points on their own, however, with a couple of scores from the Colts, and it will easily hit.

Colts vs Bills Pick

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