Read our Commanders vs 49ers pick and preview for this NFL week 16 game in Santa Clara. Check out who we like to win and cover the spread in this week’s NFL matchup.

Commanders vs 49ers Pick & Preview- NFL Week 16

The Commanders will play host to the 49ers at Levi’s Stadium in Santa Clara, CA, with a kickoff scheduled for 4:05 PM ET. The game will be televised on CBS. San Francisco heads into this NFC matchup as the 7.0-point favorite to come away with the win.

Commanders vs 49ers Matchup at a Glance

  • Sport: NFL
  • Teams: Washington Commanders at San Francisco 49ers
  • Where: Santa Clara at Levi’s Stadium
  • Date: Saturday, December 24th
  • Betting Odds SF -7.0, WAS +265 | SF -334 O/U 39.5

Will Taylor Heinicke And The Commanders Keep Things Interesting vs San Francisco?

Heading into week 16, the Washington Commanders are looking to bounce back from a divisional loss to the Giants by a score of 20-12. Leading into the matchup, the Commanders were -4.0 point favorites, resulting in both a straight-up and ATS loss. The over-under betting total going into the game was 40, which the teams did not surpass.

Throughout the game, Washington was efficient with their rushing attempts, posting 159 yards on 26 carries. Brian Robinson Jr. led the team with 89 rush yards and did not find the endzone.

Against New York, quarterback Taylor Heinicke threw for a total of 249 yards and a passer rating of 98.2. Heinicke was able to find the endzone 1 time through the air. Jahan Dotson had a big game for Washington in the passing game, coming up with 105 yards and a touchdown. Overall, Washington is the 21st-ranked team in pass yards per game, with an average of 208.6. So far, 62.17% of their yards have come through the air, on a completion percentage of 61.21% (28th).

Will The 49ers Take Care Of Business As Heavy Home Favorite?

The 49ers head into week 16 looking for another win, as they picked up 8 point victory over the Seattle Seahawks (21-13). San Francisco also picked up an ATS win, with a point spread of -3.0. The team’s combined scoring of 34 points fell below the posted betting line of 43.

Offensively, San Francisco found success in the run game, putting up 170 yards on 34 attempts. Christian McCaffrey had a big individual game, finding the endzone in addition to his 108 rush yards.

At the quarterback position, Brock Purdy ended the game with a passer rating of 116.9 on 217 yards through the air. For the game, Purdy was able to throw for 2 touchdowns. In addition to his team leading 93 receiving yards, George Kittle hauled in 2 touchdowns. As a team, San Francisco ranks 14th in the number of pass yards per game, averaging 229.43 per game. Going into the game, the 49ers have thrown a total of 7 interceptions, coming on a passing completion percentage of 65.79% (13th).

Odds & Free Betting Analysis for this NFL Game

Washington and San Francisco did not play each other in the 2021-2022 regular season.

When looking back at the recent matchups between Washington and San Francisco, the 49ers put together a record of 2-3. The two teams have combined to average 32.0 points per game in their last 5 meetings.

The Washington Commanders have gone 2-2 vs the spread in these games. The Commanders’ offense has averaged 13.6 points per game over the 5 most recent meetings with San Francisco, compared to the 49ers at 18.4.

Across their last 5 road contests, Washington has been good against the spread posting a mark of 4-1. Their overall mark in these games was 4-0-1, while averaging 20.8 points per game.

In their last 5 home games, San Francisco has averaged 25.2 points per game while allowing 16.8. The team’s record in this stretch was 4-1 while going 3-2.

Commanders vs 49ers Pick

  • Free Spread Prediction: 49ers -7.0
  • Free Total Prediction: Under 39.5